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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Ynamides and enamides providing access to valuable building blocks

Séminaire de la Professeure Laurence Miesch (Strasbourg University)

Abstract :

Ynamides and enamides are versatile synthons to create nitrogen-containing scaffolds highly prevalent in natural products that exhibit pharmacological profiles. Silver-catalyzed cyclization of ene-ynesulfonamides provide rapid access to bridged bicyclic ketoenamides, whereas keto-sulfonamides lead to spiro-enamides in a one pot fashion via keto-ynamides. Substructures of man-made psychoactive molecules of the benzodiazepine family accessible though N-imides equipped with enamides.

28/01/19

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