Iodine(III)-Mediated Halogenation Reactions & Ynamides as Ketenimines Precursors

In our group we develop synthetic methodologies that enable the construction of original molecular scaffolds possessing interesting biological properties. In particular, we try to bypass the use of unstable yet reactive intermediates by generating these species in situ. We pursue two lines of research in this direction, one deals with hypervalent iodine reagents and the second with the chemistry of ynamides. We use the former as mediators to trigger chemoselective halogenation reactions through the mild oxidation of halides. The latter are employed as readily available and stable precursors for the generation of ketenimines, which then undergo cycloaddition reactions.