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Chimie moléculaire Paris Centre

Notre École Doctorale a pour but de préparer au plus haut niveau des étudiants à une activité professionnelle dans le domaine de la chimie moléculaire en utilisant les formidables atouts dont bénéficie Paris Centre

L’ED 406 rassemble des laboratoires et des équipes répartis sur plusieurs sites et établissements d’enseignement supérieur : Université Pierre et Marie Curie, Ecoles d’Ingénieurs ESPCI et Chimie Paris Tech, Muséum National d'Histoire Naturelle, CNAM, Collège de France, ENS.


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    • Polyoxometalate Composites – from water purification to energy storage

      Séminaire du Pr Carsten Streb (Ulm University, Allemagne)
      Abstract :
      The combination of polyoxometalates – molecular metal oxide anions – with functional substrates such as nanostructured carbon or porous silica will be described as a means to access (multi)functional composite materials. Tuning of each component will be reported as a facile means of controlling reactivity and developing materials with...

    • Multi kilogram-scale synthesis of an anticancer drug candidate: a journey towards development of some key reactions

      Séminaire du Dr Christophe Hardouin (Oril Industrie)
      Abstract :
      . In order to evaluate a new drug in preclinical or clinical testing, the pharmaceutical industry needs bulk quantities of final product (from kg to hundreds of kg). Converting reactions from laboratory into industrial-scale manufacturing processes remains a challenge for process chemists while taking into account safety, legislation,...

    • Ynamides and enamides providing access to valuable building blocks

      Séminaire du Prof Laurence Miesch (Strasbourg University)
      Abstract :
      Ynamides and enamides are versatile synthons to create nitrogen-containing scaffolds highly prevalent in natural products that exhibit pharmacological profiles. Silver-catalyzed cyclization of ene-ynesulfonamides provide rapid access to bridged bicyclic ketoenamides, whereas keto-sulfonamides lead to spiro-enamides in a one pot fashion...

    • Therapy with CO: where do we stand ?

      Séminaire du Pr Carlos C. Romão (Universidade Nova de Lisboa - ITQB NOVA)
      Abstract :
      The promise to use CO (carbon monoxide) as a therapeutic principle appeared with the turn of the century following the discovery of CO’s signalling and cytoprotective effects. The ensuing research effort confirmed the therapeutic action of CO. Inhaled CO gas has been tested in many human clinical trials. Different kinds...

    • Dienals as versatile substrates for the stereoselective synthesis of polycyclic architectures.

      Séminaire du Dr Xavier Moreau (Université de Versailles Saint-Quentin-en-Yvelines)
      Abstract :
      Polycyclic architectures encompass a broad range of natural and biologically relevant products. The vast array of structural diversity and complexity reached by these molecules has fascinated synthetic organic chemists over the years. Within the context of total synthesis or synthetic chemistry methodology...

    • Synthetic RNA as Molecular Tools for the Structural and Functional Study of enzymes.

      Séminaire du Pr Mélanie Etheve-Quelquejeu (Université Paris Descartes)
      Abstract :
      .    The role of RNAs in cellular processes is one of the most dynamic areas in Biology. In addition to their key functions in protein synthesis, new RNA activities are constantly discovered. To study these different biological processes, in particular, the enzymes that interact with these RNAs, we have developed synthetic...

    • Offre d'emploi de post-doc

      Offre de post-doc chez PILI, Paris, France
      181112 - Colour Chemist - VF
      181112 - Colour Chemist - EV

    • Selective anion transport

      Séminaire du Pr Philip A. Gale (The University of Sydney, Australia)
      Abstract :
      My group is interested in designing new transporters to facilitate the transport of anions across lipid bilayer membranes and the design of new assays to measure transmembrane transport processes. Our aim is to develop selective transporters that may find application in a number of areas including the treatment of disease...

    • Chirality in Nature

      Séminaire du Dr Katsuya Inoue (Iroshima University, Japan)
      Abstract :
      .  Chirality can be found at all time and space scale in nature. In this seminar I shall explore what is important from basic particle physics to large scale natural world. I shall start from chiral spin system and show how to connect static chirality and spin chirality. Next, I shall introduce the common properties to biomolecules...

    • Organic-, coordination-chemistry and theranostic: influence of the full control of the macrocycle design on the biological properties.

      Séminaire du Prof Raphaël Tripier (Université de Brest)
      Abstract :
       If the importance of azamacrocyclic chelates in imaging (MRI, PET, optical probes) and therapy (radiotherapy) is now well establish, the challenge to find good chelators able to be used in both diagnostic and therapeutic applications persists. Indeed, there is still no “ideal” ligand able to coordinate different metallic cations of...

    • Biomolecular Hydration Shells: Dynamics and Biochemical Role

      Séminaire du Dr Damien Laage (Department of Chemistry, Ecole Normale Supérieure, PSL-SU-CNRS)
      Abstract :
      The structure and function of biomolecules are strongly influenced by their hydration shells. Two key challenges are thus first to determine the extent to which the structural and dynamical properties of these shells differ from those of bulk water, and second to elucidate the role played by water...

    • Emerging 1D and 2D d10 Coinage Metal Organic Chalcogenolate Coordination Polymers for Optical Technologies

      Séminaire du Dr Aude Demessence (IRCELYON)
      Abstract :
      Hybrid materials with chalcogenate ligands (ER = SR, SeR, TeR) and d10 coinage metals (M(I) = Cu, Ag and Au) are known for a long time mainly in the domains of biology and pharmaceutics. Indeed, copper-thiolates are present in most of the living organisms as metalloproteins, silver-thiolates are recognized for their anti-bacterial activity and some...

    • Platforms for the generation and high-throughput screening of SICLOPPS cyclic peptide libraries.

      Séminaire du Prof Ali Tavassoli (University of Southampton)
      Abstract :
      Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein– protein interactions. SICLOPPS is a method for the intracellular generation of cyclic peptide libraries of over a hundred million members. We have interfaced SICLOPPS libraries with a variety of cell-based...

    • Development of radical based synthetic strategies for the total synthesis of natural products and Posttranslational modification of proteins

      Séminaire du Prof Heeyon Lee (Korean Advanced Institute of Science & Technology)
      Abstract :
      Tandem cycloaddition reaction of allenyldiazao precursor vis via trimethylenemethane(TMM)-diyl was developed to contruct complex polycyclic structures in a single operation. This TMM-diyl cycloaddition reaction was successfully applied to the total synthesis of natural products with very challenging structural...

    • Engineering catalytic sites and molecular recognition in designed peptide scaffolds

      Séminaire du Dr Olga Iranzo (Institut des Sciences Moléculaires de Marseille - UMR CNRS 7313 Aix-Marseille Université)
      Abstract :
      Peptide-based frameworks constitute very attractive and versatile platforms for the development of novel systems with tailor-made properties and functionalities. They are chiral and have structural and chemical diversity (proteinogenic and non-proteinogenic amino acids),...

    • Heterocycles from the sea, a light from the abyss

      Séminaire du Dr Yves L. Janin (CNRS - Institut Pasteur)
      Abstract :
      A growing proportion of bioluminescent reporting systems are using imidazo[1,2-∝]pyrazine luciferins such as the natural product coelenterazine or the analog furimazine along with photoproteins or luciferases from sea creatures. Our contribution has led to an original (gram-scale) synthesis of this heterocyclic system, the preparation...

    • Bio-inspired peptide-like ligands to help understanding metal toxicity, regulation and detoxification

      Séminaire du Dr Pascale Delangle (CEA Grenoble, France)
      Abstract :
      Peptides are promising metal-chelating agents, which offer many advantages over synthetic chemical compounds for biological and medical applications. They are made of the same building blocks as proteins and are therefore excellent mimics of biological sites that help predicting high affinity metal binding environments in vivo. They...

    • Dearomatizations of Nitroarenes by additions and cycloadditions

      Séminaire du Dr Isabelle Chataigner (Université de Rouen Normandie)
      Abstract :
      . Involving arenes in dearomatizing addition and/or cycloaddition reactions is an attractive and convergent approach to construct complex polycycles from easily accessible substrates, however, challenging because of their intrinsic stability.
      Nitroarenes are interesting substrates in this context, allowing to carry out various...

    • Campagne de candidature des Chargés de missions doctorales

      La campagne de candidature des Chargés de missions doctorales ouvrira du lundi 11 juin au mercredi 22 août 2018.
      Dépôt des candidatures sur le site internet :
      Vérification des conditions d'éligibilité sur la page :
      Les doctorants qui ont déjà commencé une mission cette année ne doivent pas se réinscrire

    • Liste des candidats reçus

      Liste principale des candidats reçus
      Liste principale des candidats financés par lED406 - Allocataires 2018

    • Turning Capsule Catalysis Inside Out: Novel Approaches Utilizing Innately-Polarized Pd2L4 Scaffolds

      Séminaire du Dr Paul Lusby (Edinburgh University)
      Substrate pre-organization remains the paradigm for bio-inspired catalytic strategies using supramolecular capsule systems. The scarcity of capsule-catalyzed annulation reactions (A+B→C) highlights the limitation of this approach—while co-encapsulation can give significant acceleration, product inhibition frequently halts turnover.1,2 In this...

    • Journées de chimie moléculaire

      Les 18e Journées de Chimie Moléculaire se dérouleront les 5 et 6 juin 2018.

    • Ecole d'été ISOS 2018

      Ecole d'été du 10 au 14 juin 2018

    • Annonce Postdocs Paris

      Annonce de 4 Postdocs en Chimie Organique à Paris (Cnam et ESPCI) à pourvoir urgemment
      POSTDOCTORAL Positions in Organic Chemistry Paris

    • Annonce Postdoc_Vinci

      Allocation de bourse postdoctorale (CDD 12 mois)
      Annonce Postdoc_Vinci_April 2018

    • Journée de Rentrée de l'Ecole Doctorale de Chimie Moléculaire

      La Journée de Rentrée de l'Ecole Doctorale de Chimie Moléculaire aura lieu le lundi 5 février 2018 à partir de 13h à l'amphi 43
      Objet :
      Les doctorants de première année présentent leur parcours et leur projet doctoral en une durée limitée à environ 5 minutes.

    • Proposition de thèse

      Proposition de thèse pour une CIFRE Chimie ParisTech :
      Sujet de thèse proposé par V. Vidal et P. Phansavath

    • Journées bibliographiques

      Les 16e Journées bibliographiques ont eu lieu les 8 et 9 février 2016

Mots clés

Synthèse organique, catalyse organométallique, chimie des substances naturelles ; réactions de couplage, radicalaires, domino ; catalyse asymétrique ; processus éco-compatibles. 

Synthèse et manipulation de biomolécules ; protéomique et spectrométrie de masse. 

Etude structure et réactivité d’enzymes ; chimie bio-organométallique. Synthèse inorganique, espèces polymétalliques ; complexes bio-inspirés ; catalyse de polymérisation biosourcée. 

Matériaux moléculaires pour l’ (opto)-électronique et le magnétisme, photovoltaïsme. 

Chimie supramoléculaire, cyclodextrines. Analyse et catalyse électrochimiques, biocapteurs electroanalytiques, sondes multimodales pour l’imagerie.


Traductions :


    Directeur (cyril.ollivier @


    Directeur adjoint




    Irène Rasoarinoro (irene.rasoarinoro @

    Tel. : 01 44 27 38 48


    UPMC - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5